Ultra-fast proteomics search engine. Regular searches - when the precursor mass is limited to a narrow window of several ppm - are done within a few seconds. An “open-search” (with large precursor mass range tolerance, e.g. +/-500 Da) for a 2 hour LC gradient bottom-up proteomics experiment can be done in a minute or so on a laptop.
Andy T. Kong, Felipe V. Leprevost, Dmitry M. Avtonomov, Dattatreya Mellacheruvu, Alexey I. Nesvizhskii. MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry–based proteomics. In Nature Methods, 2017.